Biomechanics, Computational Mechanics
Mechanical Analysis and Investigation of Functional Adaptation Mechanisms in Living Objects Leading to Engineering Applications
Living tissue adapts to its surrounding environment by remodeling with hierarchical structures from nano- to macroscopic levels. For example, the macroscopic load-supporting function of bone is a result of mechanical adaptation achieved by microscopic trabecular bone remodeling.
Remodeling is defined as coupled formation and resorption by cellular activities, such as those performed by osteoblasts and osteoclasts, leading to changes in the morphology and mechanical properties of bone.
We investigate mechanisms of mechanical adaptation in such biological objects produced by interactions between hierarchical structures for the development of new machine structures and materials. We study self-diagnosis, self-healing, and adaptation functions from a biomechanical perspective. Using computer simulation and an experimental approach, we focus specifically on the assessment of bone fracture risks, the prediction of change in mechanical properties of bone by its remodeling, and the elucidation of mechanisms of mechano-sensors in actin cytoskeletal structures of a cell.
We are looking for collaborators in the development of medical machines and devices, and in the mechanical evaluation of new materials or biological materials.